The antidiabetic effect of thymoquinone: A systematic review and meta-analysis of animal studies

被引:13
|
作者
Bule, Mohammed [1 ,2 ,3 ]
Nikfar, Shekoufeh [4 ,5 ]
Amini, Mohsen [1 ,2 ]
Abdollahi, Mohammad [1 ,6 ]
机构
[1] Univ Tehran Med Sci, Pharmaceut Sci Res Ctr, Inst Pharmaceut Sci TIPS, Toxicol & Dis Grp, Tehran, Iran
[2] Univ Tehran Med Sci, Fac Pharm, Dept Med Chem, Tehran, Iran
[3] Ambo Univ, Coll Med & Hlth Sci, Dept Pharm, Ambo, Ethiopia
[4] Univ Tehran Med Sci, Fac Pharm, Dept Pharmacoecon & Pharmaceut Adm, Tehran, Iran
[5] Univ Tehran Med Sci, Personalized Med Res Ctr, Endocrinol & Metab Clin Sci Inst, Tehran, Iran
[6] Univ Tehran Med Sci, Fac Pharm, Dept Toxicol & Pharmacol, Tehran, Iran
基金
美国国家科学基金会;
关键词
Antidiabetic; Black cumin; Diabetes; Nigella saliva L; Thymoquinone; Meta-analysis; Systematic review; NIGELLA-SATIVA OIL; BLACK CUMIN OIL; DIABETES-MELLITUS; OXIDATIVE STRESS; STREPTOZOTOCIN; CONSTITUENT; GLUCOSE; NEPHROPATHY; NEUROPATHY; STABILITY;
D O I
10.1016/j.foodres.2019.108736
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
Thymoquinone (2-isopropyl-5-methylbenzo-1, 4-quinone) (TQ) is a quinone derivative with a yellow crystalline appearance, abundantly found in black cumin, Nigella sativa L. TQ has diverse pharmacological properties. The aim of this systematic review on the antidiabetic effects of TQ is to evaluate the currently available evidence and conduct meta-analysis. A literature search of articles published until 25 January 2019 was done on PubMed, EMBASE, Web of Sciences and Scopus databases, using relevant keywords. The meta-analysis included 18 studies that examined the serum glucose (SG) level or serum insulin level or body weight (BW). In the meta-analysis it was found that with an overall pooled standardized mean difference (SMD) of - 9.176 mg/dl (95%CI: - 10.759, - 7.593; p = 0.000); TQ reduced the SG level (- 9.176 mg/dl) significantly in the STZ-induced diabetes model. Moreover, a meta-analysis of the effect of TQ on BW demonstrated that TQ has a statistically significant effect on the BW of diabetic animals with an overall pooled SMD of 4.509 (95%CI: 3.234, 5.784; p = 0.000). In addition, the overall pooled estimate of the level of serum insulin was significant with SMD of 1.681 (95%CI: 0.858, 2.503; p = 0.000). Therefore, the meta-analysis showed that TQ has a significant antidiabetic effect through its action on the SG, serum insulin level, and BW of the animals.
引用
收藏
页数:10
相关论文
共 50 条
  • [1] Antidiabetic effect of quercetin: A systematic review and meta-analysis of animal studies
    Bule, Mohammed
    Abdurahman, Ahmed
    Nikfar, Shekoufeh
    Abdollahi, Mohammad
    Amini, Mohsen
    [J]. FOOD AND CHEMICAL TOXICOLOGY, 2019, 125 : 494 - 502
  • [2] The effect of SSRIs on unconditioned anxiety: a systematic review and meta-analysis of animal studies
    Heesbeen, Elise J.
    van Kampen, Tatum
    Verdouw, P. Monika
    van Lissa, Caspar
    Bijlsma, Elisabeth Y.
    Groenink, Lucianne
    [J]. PSYCHOPHARMACOLOGY, 2024, 241 (09) : 1731 - 1755
  • [3] Introduction to systematic review and meta-analysis of preclinical animal studies
    de Vries, R.
    [J]. JOURNAL OF SLEEP RESEARCH, 2018, 27
  • [4] Effect of age on ischaemic stroke outcomes: A systematic review and meta-analysis of animal studies
    McCann, S.
    Cruz, F.
    Rackoll, T.
    Hair, K.
    Dirnagl, U.
    Sena, E.
    [J]. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2022, 42 (1_SUPPL): : 231 - 231
  • [5] The effect of nitroglycerin treatment on cerebral ischaemia: A systematic review and meta-analysis of animal studies
    Litman, Magdalena
    Spratt, Neil J.
    Beard, Daniel J.
    [J]. NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 2024, 151 : 10 - 16
  • [6] The effect of quercetin on diabetic nephropathy (DN): a systematic review and meta-analysis of animal studies
    Hu, Tingyan
    Yue, Junlun
    Tang, Qiuwen
    Cheng, Ka-Wing
    Chen, Feng
    Peng, Mijun
    Zhou, Qian
    Wang, Mingfu
    [J]. FOOD & FUNCTION, 2022, 13 (09) : 4789 - 4803
  • [7] Polyphyllins in cancer therapy: A systematic review and meta-analysis of animal studies
    Bai, Yan
    Li, Mengmeng
    Geng, Dongjie
    Liu, Shouzan
    Chen, Ye
    Li, Shan
    Zhang, Shaobo
    Wang, Hongzhen
    [J]. PHYTOMEDICINE, 2023, 121
  • [8] Moxibustion for cognitive impairment: A systematic review and meta-analysis of animal studies
    Aum, Sungmin
    Choe, Seon
    Cai, Mudan
    Jerng, Ui Min
    Lee, Jun-Hwan
    [J]. INTEGRATIVE MEDICINE RESEARCH, 2021, 10 (02)
  • [9] Effect of Ganoderma lucidum on serum lipid profiles: A systematic review and meta-analysis on animal studies
    Aref, Maryam
    Khoshhali, Mehri
    Ghasemi, Pouria
    Adeli, Shaghayegh
    Heidari-Beni, Motahar
    Kelishadi, Roya
    [J]. JOURNAL OF RESEARCH IN MEDICAL SCIENCES, 2023, 28 (01):
  • [10] The effect of rapamycin treatment on cerebral ischemia: A systematic review and meta-analysis of animal model studies
    Beard, Daniel J.
    Hadley, Gina
    Thurley, Neal
    Howells, David W.
    Sutherland, Brad A.
    Buchan, Alastair M.
    [J]. INTERNATIONAL JOURNAL OF STROKE, 2019, 14 (02) : 137 - 145