Recent Progress in the Use of Pd-Catalyzed C-C Cross-Coupling Reactions in the Synthesis of Pharmaceutical Compounds

被引：75

作者：

Biajoli, Andre F. P. ^{[1
]}

Schwalm, Cristiane S. ^{[1
]}

Limberger, Jones ^{[1
]}

Claudino, Thiago S. ^{[1
]}

Monteiro, Adriano L. ^{[1
]}

机构：

[1] Univ Fed Rio Grande do Sul, Inst Chem, Lab Mol Catalysis, BR-91501970 Porto Alegre, RS, Brazil

来源：

JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY | 2014年 / 25卷 / 12期

关键词：

cross-coupling reactions; Heck reactions; palladium; pharmaceuticals; CARBON BOND FORMATION; PRACTICAL SYNTHESIS; HECK REACTION; RECEPTOR ANTAGONIST; KINASE INHIBITOR; DIAZONIUM SALTS; LARGE-SCALE; ORGANOBORON COMPOUNDS; SCALABLE SYNTHESIS; KILOGRAM SCALE;

D O I：

10.5935/0103-5053.20140255

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The impressive ability of palladium to assemble C-C bonds between appropriately functionalized substrates has allowed synthetic organic chemists to perform transformations that were previously impossible or only possible using multi-step approaches. In this context, one of the most important and elegant applications of the Pd-catalyzed C-C coupling reactions currently is the synthesis of pharmaceuticals. This review is intended to give a picture of the applications of Pd-catalyzed C-C cross-coupling reactions for the synthesis of drug components or drug candidates regardless of the scale from 2011 through to the end of July, 2014.

引用

页码：2186 / 2214

页数：29

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