Role of mast cells in antigen-induced airway inflammation and bronchial hyperresponsiveness in rats

被引：3

作者：

Kawada, N ^{[1
]}

Tanaka, H ^{[1
]}

Takizawa, T ^{[1
]}

Yamada, T ^{[1
]}

Takahashi, Y ^{[1
]}

Masuda, T ^{[1
]}

Inagaki, N ^{[1
]}

Nagai, H ^{[1
]}

机构：

[1] Gifu Pharmaceut Univ, Dept Pharmacol, Gifu 5028585, Japan

来源：

JAPANESE JOURNAL OF PHARMACOLOGY | 2001年 / 85卷 / 03期

关键词：

airway inflammation; bronchial hyperresponsiveness; Brown-Norway rat; mast cell; Ws/Ws rat;

D O I：

10.1254/jjp.85.250

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The participation of mast cells in the induction of antigen-induced airway inflammation and bronchial hyperresponsiveness (BHR) to acetylcholine (ACh) was investigated using pharmacological agents and mast cell-deficient rats (Ws/Ws). A significant increase in the number of leukocytes in bronchoalveolar lavage fluid (BALF) and bronchial responsiveness to ACh were observed 24 h after antigen (ovalbumin) challenge in sensitized Brown-Norway (BN) rats. Disodium cromoglycate and terfenadine did not inhibit antigen-induced airway inflammation and BHR in sensitized BN rats. In contrast, cyclosporin A (CyA), FK-506 and prednisolone significantly inhibited antigen-induced airway inflammation and BHR in sensitized BN rats. In addition, disodium cromoglycate, terfenadine and prednisolone, but not CyA and FK-506, inhibited homologous passive cutaneous anaphylaxis in rats. Furthermore, a significant increase in the number of leukocytes in BALF and BHR was also observed in Ws/Ws rats 24 h after inhalation of antigen; however, the magnitude of BHR in Ws/Ws rats was lower than that in the congenic rats. These findings suggest that mast cells play a partial role in the development of antigen-induced BKR in rats and that the induction of BHR is barely suppressed by mast cell stabilizing agents.

引用

页码：250 / 259

页数：10

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