In Vitro Biocompatibility of PLGA-HA Nano-Hybrid Scaffold

Previously, a hybrid non woven mesh comprising nano-fibers of hyaluronic acid (HA) and poly (DL-lactic-co-glycolic acids) (PLGA) was prepared using multi-electro-spinning as a scaffold material for tissue engineering applications. HA nano-fibers on the surface provided the improved wettability to the culture medium as well as the possibilities for the enhanced cell attachment and proliferation. As continuation study, biocompatibility profiles of the hybrid scaffold were investigated in vitro, using a series of cytotoxicity tests, and compared with those of high density polyethylene (HDPE) and polyurethane (PU). The PLGA-HA nano-hybrid scaffold showed the negligible toxic influence in all cell culture tests, which was attributed to hydrophilic nature of HA nano-fibers.