Facile synthesis of thermo- and pH-responsive biodegradable microgels

被引：26
|
作者：
Zhao, Changwen [1 ]
Gao, Xiaoye [1 ,2 ]
He, Pan [1 ,2 ]
Xiao, Chunsheng [1 ,2 ]
Zhuang, Xiuli [1 ]
Chen, Xuesi [1 ]
机构：
[1] Chinese Acad Sci, Changchun Inst Appl Chem, Key Lab Polymer Ecomat, Changchun 130022, Peoples R China
[2] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
来源：
COLLOID AND POLYMER SCIENCE | 2011年 / 289卷 / 04期
基金：
中国国家自然科学基金;
关键词：
Thermo-responsive; pH-responsive; Microgels; Polypeptide; Biodegradable; ACID N-CARBOXYANHYDRIDES; POLY(L-GLUTAMIC ACID); DRUG-DELIVERY; CONTROLLED-RELEASE; GRAFT-COPOLYMERS; TEMPERATURE; POLY(N-ISOPROPYLACRYLAMIDE); POLYPEPTIDES; RANGE;
D O I：
10.1007/s00396-010-2365-9
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
A novel and facile strategy has been designed to prepare biodegradable microgels with thermo- and pH-responsive property. The microgels were synthesized by the crosslinking of N-isopropylacrylamide with vinyl groups functionalized poly(L-glutamic acid) (PGA). The resultant microgels exhibited pH-dependent phase transition behaviors in aqueous solutions and underwent abrupt lower critical solution temperature decrease when the pH was reduced below the pK (a) of PGA. Dynamic light scattering measurement revealed that the microgels exhibited shrinkage as the temperature increased or the pH decreased.
引用
收藏
页码：447 / 451
页数：5
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