DIETARY ACID LOAD AND RISK OF KIDNEY CANCER: AN EPIDEMIOLOGIC CASE-CONTROL STUDY

被引:0
|
作者
Ronco, A. L. [1 ,2 ,3 ]
Storz, M. A. [4 ]
Martinez-Lopez, W. [5 ,6 ,7 ]
Calderon, J. M. [3 ]
Golomar, W. [8 ]
机构
[1] Pereira Rossell Womens Hosp, Unit Oncol & Radiotherapy, Montevideo, Uruguay
[2] CLAEH Univ, Sch Med, Maldonado, Uruguay
[3] Univ Montevideo, Biomed Sci Ctr, Montevideo, Uruguay
[4] Univ Freiburg, Ctr Complementary Med, Dept Internal Med 2, Fac Med, Freiburg, Germany
[5] Inst Invest Biol Clemente Estable, Genet Dept, Montevideo, Uruguay
[6] Inst Invest Biol Clemente Estable, Biodosimetry Serv, Montevideo, Uruguay
[7] Univ Republica, Acad Unit Radiat Protect, Fac Med, Montevideo, Uruguay
[8] Natl Canc Inst, Dept Med Oncol, Montevideo, Uruguay
关键词
Diet; Dietary acid load; Renal cancer; Kidney cancer; Epidemiology; NEAP; PRAL; Nutrition; RENAL-CELL CARCINOMA; VEGETABLES; EXCRETION; PATTERNS; ASSOCIATION; POTASSIUM; CHILDREN; PROTEIN; FRUIT;
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Objective: Recent research studies linked the intake of processed meat and fatty foods to an increased risk of renal cell carcinoma. Fruits and vegetables, on the other hand, may convey protective effects. Dietary acid load (DAL) has been proposed as a potential risk factor for various cancer types within the last years. The present study sought to explore potential associations between this novel risk factor and renal cancer. Patients and Methods: A case-control study was performed in 114 cases and 864 age-frequency matched controls (978 patients) through a multi-topic inquiry, including a food frequency questionnaire. DAL was calculated based on two commonly used formulas: Potential Renal Acid Load (PRAL) score and Net Endogenous Acid Production (NEAP) score. Odds ratios (OR) and their 95% confidence intervals were estimated by logistic regression, adjusted for potential confounders. Results: We found no significant statistical associations between DAL and kidney cancer risk. The OR for the highest tertiles of scores were: PRAL (=0.91), NEAP (=1.59), and NEAPr (=0.87). All observed trends were non-significant. Conclusions: Although previous studies showed direct, significant associations between a high DAL and risk of certain cancers, we were unable to observe such an association in the present study. Our results indicate that other dietary components that are not related to alkalizing/acidifying properties might explain the interactions between nutrition and kidney cancer. Since to our knowledge, our study is the first epidemiologic report on DAL and renal cancer risk, and further research is warranted to confirm the present findings.
引用
收藏
页数:8
相关论文
共 50 条
  • [1] Dietary acid load and esophageal cancer risk: A case-control study
    Luis Ronco, Alvaro
    Martinez-Lopez, Wilner
    Calderon, Juan M.
    Storz, Maximilian Andreas
    [J]. THORACIC CANCER, 2022, 13 (19) : 2759 - 2766
  • [2] DIETARY ACID LOAD AND RISK OF GASTRIC CANCER: A CASE-CONTROL STUDY
    Ronco, A. L.
    Martinez-Lopez, W.
    Calderon, J. M.
    Mendoza, B.
    Storz, M. A.
    [J]. WORLD CANCER RESEARCH JOURNAL, 2022, 9
  • [3] DIETARY ACID LOAD AND COLORECTAL CANCER RISK: A CASE-CONTROL STUDY
    Ronco, A. L.
    Martinez-Lopez, W.
    Calderon, J. M.
    Mendoza, B.
    [J]. WORLD CANCER RESEARCH JOURNAL, 2020, 7
  • [4] Dietary acid load and breast cancer risk: A case-control study in Uruguay
    Ronco, A.
    Calderon, J.
    Mendoza, B.
    [J]. EUROPEAN JOURNAL OF CANCER, 2020, 138 : S122 - S122
  • [5] DIETARY ACID LOAD AND RISK OF CANCER: NEW INSIGHTS FROM A NATIONWIDE CASE-CONTROL STUDY
    Ronco, A. L.
    Martinez-Lopez, W.
    Calderon, J. M.
    Mintegui, G.
    Storz, M. A.
    [J]. WORLD CANCER RESEARCH JOURNAL, 2023, 10
  • [6] Dietary acid load and risk of diminished ovarian reserve: a case-control study
    Ziaei, Rahele
    Ghavami, Abed
    Ghasemi-Tehrani, Hatav
    Movahedi, Minoo
    Hashemi, Maryam
    Hajhashemi, Maryam
    Elyasi, Mahshid
    Vajdi, Mahdi
    Kalatehjari, Maryam
    [J]. REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY, 2024, 22 (01)
  • [7] Dietary insulin index and load with risk of breast cancer in a case-control study
    Akbari, Atieh
    Sohouli, Mohammad Hassan
    Lozovanu, Oana Deliu
    Lotfi, Mojtaba
    Nabavizadeh, Raheleh
    Saeidi, Reza
    [J]. INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, 2021, 75 (12)
  • [8] Dietary acid load and risk of type 2 diabetes mellitus: A case-control study
    Hatami, Elaheh
    Abbasi, Khadijeh
    Salehi-Sahlabadi, Ammar
    Beigrezaei, Sara
    Bahrami, Alireza
    Ghiasvand, Reza
    Pourmasoumi, Makan
    [J]. CLINICAL NUTRITION ESPEN, 2022, 48 : 308 - 312
  • [9] A Case-Control Study on Dietary Acid Load in Relation to Glioma
    Milajerdi, Alireza
    Shayanfar, Mehdi
    Benisi-Kohansal, Sanaz
    Mohammad-Shirazi, Minoo
    Sharifi, Giuve
    Tabibi, Hadi
    Esmaillzadeh, Ahmad
    [J]. NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 2022, 74 (05): : 1644 - 1651
  • [10] Dietary glycemic index and glycemic load, and breast cancer risk: A case-control study
    Augustin, LSA
    Dal Maso, L
    Vecchia, CL
    Parpinel, M
    Negri, E
    Vaccarella, S
    Kendall, CWC
    Jenkins, DJA
    Franceschi, S
    [J]. ANNALS OF ONCOLOGY, 2001, 12 (11) : 1533 - 1538