JAK-STAT pathway in carcinogenesis: Is it relevant to cholangiocarcinoma progression?

被引：29
|
作者：
Smirnova, Olga V. [1 ]
Ostroukhova, Tatiana Yu [1 ]
Bogorad, Roman L. [2 ,3 ]
机构：
[1] Moscow MV Lomonosov State Univ, Fac Biol, Lab Endocrinol, Moscow 119992, Russia
[2] INSERM, U845, Paris, France
[3] Univ Paris 05, Fac Med Rene Descartes, Ctr Rech Croissance & Signalisat, Equipe PRL,GH & Tumours, F-75015 Paris, France
来源：
WORLD JOURNAL OF GASTROENTEROLOGY | 2007年 / 13卷 / 48期
关键词：
cholangiocarcinoma; janus tyrosine kinases; signal transducers and activators of transcription; prolactin; interleukin-6; cytokine receptors; receptor tyrosine kinases;
D O I：
10.3748/wjg.13.6478
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
The features of JAK-STAT signaling in liver cells are discussed in the current review. The role of this signaling cascade in carcinogenesis is accentuated. The possible involvement of this pathway and alteration of its elements are compared for normal cholangiocytes, cholangiocarcinoma predisposition and development. Prolactin and interleukin-6 are described in detail as the best studied examples. In addition, the non-classical nuclear translocation of cytokine receptors is discussed in terms of its possible implication to cholangiocarcinorna development. (C) 2007 WJG. All rights reserved.
引用
收藏
页码：6478 / 6491
页数：14
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