Fungal Infections of the Central Nervous System in Children

被引：21

作者：

McCarthy, Matthew W. ^{[1
]}

Kalasauskas, Darius ^{[2
,3
]}

Petraitis, Vidmantas ^{[3
,4
]}

Petraitiene, Ruta ^{[3
,4
]}

Walsh, Thomas J. ^{[3
,5
,6
]}

机构：

[1] Cornell Univ, Weill Cornell Med, Div Gen Internal Med, New York, NY 10021 USA

[2] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Dept Neurosurg, Mainz, Germany

[3] Cornell Univ, Weill Cornell Med, Dept Med, Transplantat Oncol Infect Dis Program,Div Infect, New York, NY 10021 USA

[4] Inst Infect Dis & Pathogen Microbiol, Prienai, Lithuania

[5] Cornell Univ, Weill Cornell Med, Dept Pediat, New York, NY 10021 USA

[6] Cornell Univ, Weill Cornell Med, Dept Microbiol & Immunol, New York, NY 10021 USA

来源：

JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY | 2017年 / 6卷 / 03期

关键词：

aspergillosis; Candida meningoencephalitis; CNS; cryptococcosis; fungal infections; mucormycosis; HEMATOGENOUS CANDIDA MENINGOENCEPHALITIS; CLINICAL-PRACTICE GUIDELINES; INVASIVE MOLD INFECTIONS; BIRTH-WEIGHT INFANTS; CRYPTOCOCCUS-NEOFORMANS; DISEASES-SOCIETY; DISSEMINATED HISTOPLASMOSIS; RHINOCEREBRAL MUCORMYCOSIS; MULTICENTER EVALUATION; NEONATAL CANDIDIASIS;

D O I：

10.1093/jpids/pix059

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Although uncommon in children, fungal infections of the central nervous system can be devastating and difficult to treat. A better understanding of basic mycologic, immunologic, and pharmacologic processes has led to important advances in the diagnosis and management of these diseases, but their mortality rates remain unacceptably high. In this focused review, we examine the epidemiology and clinical features of the most common fungal pathogens of the central nervous system in children and explore recent advances in diagnosis and antifungal therapy.

引用

页码：E123 / E133

页数：11

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