Further application of an N-Ar axially chiral mimetic-type ligand: Asymmetric Grignard cross-coupling reaction

被引：24
|
作者：
Horibe, H
Kazuta, K
Kotoku, M
Kondo, K
Okuno, H
Murakami, Y
Aoyama, T
机构：
[1] Toho Univ, Fac Pharmaceut Sci, Funabashi, Chiba 2748510, Japan
[2] Nagoya City Univ, Grad Sch Pharmaceut Sci, Mizuho Ku, Nagoya, Aichi 4678603, Japan
来源：
SYNLETT | 2003年 / 13期
关键词：
N-Ar axis; chiral mimetics; optically active ligand; Grignard cross-coupling; asymmetric Kumada-Corriu reaction;
D O I：
10.1055/s-2003-41485
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel chiral ligand mimicking N-Ar axial chirality, (S)-N-[2-(diphenylphosphanyl)naphthalen-1-yl]-2-(piperidinylmethyl)piperidine, was found to exhibit good enantio selectivity (up to 80% ee) in the asymmetric cross-coupling reaction of 1-phenylethylmagnesium chloride with beta-bromostyrene derivatives. Additionally, this type ligand is appealing, because it allows the synthesis of a wide variety of analogues.
引用
收藏
页码：2047 / 2051
页数：5
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