Disciplined approach to drug discovery and early development

被引：66

作者：

Plenge, Robert M. ^{[1
]}

机构：

[1] Merck Res Labs, Boston, MA 02115 USA

来源：

SCIENCE TRANSLATIONAL MEDICINE | 2016年 / 8卷 / 349期

关键词：

DEVELOPMENT PRODUCTIVITY; PHARMACEUTICAL-INDUSTRY; LESSONS; TARGETS; CHALLENGE; MEDICINES; ATTRITION; CANCER; RATES;

D O I：

10.1126/scitranslmed.aaf2608

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Our modern health care system demands therapeutic interventions that improve the lives of patients. Unfortunately, decreased productivity in therapeutics research and development (R&D) has driven drug costs up while delivering insufficient value to patients. Here, I discuss a model of translational medicine that connects four components of the early R&D pipeline-causal human biology, therapeutic modality, biomarkers of target modulation, and proof-of-concept clinical trials. Whereas the individual components of this model are not new, technological advances and a disciplined approach to integrating all four areas offer hope for improving R&D productivity.

引用

页数：5

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