Screening and Early Detection of Lung Cancer

被引：47

作者：

van't Westeinde, Susan C. ^{[1
]}

van Klaveren, Rob J. ^{[1
]}

机构：

[1] Erasmus MC, Dept Pulmonol, NL-3015 CE Rotterdam, Netherlands

来源：

CANCER JOURNAL | 2011年 / 17卷 / 01期

关键词：

Cancer screening; lung neoplasms; biomarkers; exhaled breath; multidetector CT scan; LOW-DOSE CT; RANDOMIZED CONTROLLED-TRIAL; AUTOMATED SPUTUM CYTOMETRY; EXHALED BREATH CONDENSATE; FLIGHT MASS-SPECTROMETRY; GUIDELINES 2ND EDITION; CIRCULATING PLASMA DNA; BASE-LINE-FINDINGS; COMPUTED-TOMOGRAPHY; PROMOTER HYPERMETHYLATION;

D O I：

10.1097/PPO.0b013e3182099319

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Lung cancer with an estimated 342,000 deaths in 2008 (20% of total) is the most common cause of death from cancer, followed by colorectal cancer (12%), breast cancer (8%), and stomach cancer (7%) in Europe. In former smokers, the absolute lung cancer risk remains higher than in never-smokers; these data therefore call for effective secondary preventive measures for lung cancer in addition to smoking cessation programs. This review presents and discusses the most recent advances in the early detection and screening of lung cancer. An overview of randomized controlled computerized tomography-screening trials is given, and the role of bronchoscopy and new techniques is discussed. Finally, the approach of (noninvasive) biomarker testing in the blood, exhaled breath, sputum, and bronchoscopic specimen is reviewed.

引用

页码：3 / 10

页数：8

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