Treatment intensification for patients with type 2 diabetes and poor glycaemic control

Aims: To identify the time to and patient characteristics associated with treatment intensification in patients with type 2 diabetes (T2D) and poor glycaemic control. Methods: Using a large US insurance claims database, we conducted a retrospective cohort study among adult patients with T2D and glycated haemoglobin (HbA1c) >= 8% (index date) after >= 3 months of therapy including metformin. Patients were required to have continuous enrolment for at least 12 months before (baseline) and after index date, and no injectable antidiabetes medications. We defined treatment intensification as prescription fill for injectable or additional oral antidiabetic drugs (OADs). Cox modelling was performed to identify factors associated with time to treatment intensification. Results: For the 11 525 patients meeting the inclusion criteria, the mean age at index date was 57 years, 40% were female and the mean index HbA1c was 9.1%. Overall, 37% of patients had their treatment intensified < 6 months after, 11% had their treatment intensified 6-12 months after, and 52% did not have their treatment intensified < 12 months after the index date. A higher index HbA1c was associated with early intensification [ hazard ratio (HR) 1.18 for HbA1c >= 9 to < 10% and HR 1.41 for HbA1c >= 10% compared with HbA1c >= 8 to < 9%; p < 0.0001), and later line of therapy was associated with late intensification (HR 0.78 for metformin with one OAD and HR 0.68 for metformin with >= 2 OADs compared with metformin monotherapy; p < 0.0001). Conclusions: Fewer than half of patients with T2D and treatment failure received intensification within 12 months in a real-world US population. Factors associated with treatment inertia can be used to target clinical care for these patients. Keywords: database research, observational study