An automated radiosynthesis of [18F]DPA-714 on a commercially available radiosynthesizer, Elixys Flex/Chem

被引：5
|
作者：
McCauley, Katelyenn S. [1 ]
Wilde, Justin H. [1 ]
Bufalino, Sophia M. [3 ]
Neumann, Kiel D. [1 ,2 ]
机构：
[1] Univ Virginia, Dept Radiol & Med Imaging, Charlottesville, VA 22903 USA
[2] Univ Virginia, Emily Cour Clin Canc Ctr, Charlottesville, VA 22903 USA
[3] Univ Virginia, Dept Chem, Charlottesville, VA 22903 USA
来源：
APPLIED RADIATION AND ISOTOPES | 2022年 / 180卷
关键词：
Fluorine-18; F-18; Positron emission tomography; Radiosynthesis; Radiochemistry; Automation; PROTEIN; 18; KDA; INITIAL EVALUATION; LIGAND; TSPO; NEUROINFLAMMATION; MICROGLIA; BINDING; DISEASE;
D O I：
10.1016/j.apradiso.2021.110032
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
[F-18]DPA-714 is a radiotracer specific to the translocator protein (TSPO) and is useful for in vivo Positron Emission Tomography imaging studies. In this report, we have developed an automated radiosynthesis of [F-18] DPA-714 on a commercially-available radiosynthesis platform, which comports with USP <823> guidelines. The wide availability of the radiosynthesis module and ease of dissemination of the production sequence will facilitate preclinical and clinical research of TSPO-related pathology.
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页数：6
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