An improved formal total synthesis of (-)-anisomycin

被引：18
|
作者：
Huang, PQ [1 ]
Zheng, X [1 ]
机构：
[1] Xiamen Univ, Dept Chem, Xiamen 361005, Fujian, Peoples R China
来源：
ARKIVOC | 2003年
关键词：
anisomycin; malic acid; reductive alkylation; asymmetric synthesis; malimide;
D O I：
10.3998/ark.5550190.0004.202
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
(R)-1-Benzyloxycarbonyl-2-(4-methoxyphenyl) methyl-3-pyrroline 14 was synthesized from (S)-N, O-dibenzyl malimide 5 via a highly regio and trans stereoselective reductive alkylation of 5. This constitutes an improved formal asymmetric synthesis of natural (-)- anisomycin.
引用
收藏
页码：7 / 14
页数：8
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