Still entangled: Assembly of the central spindle by multiple microtubule modulators

被引：44
|
作者：
Douglas, Max E. [1 ]
Mishima, Masanori [1 ]
机构：
[1] Univ Cambridge, Wellcome Trust Canc Res UK Gurdon Inst, Cambridge CB2 1QN, England
来源：
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2010年 / 21卷 / 09期
基金：
英国生物技术与生命科学研究理事会;
关键词：
Central spindle; Microtubule bundle; MKLP1; CYK4; PRC1; KINESIN-LIKE PROTEIN; GTPASE-ACTIVATING PROTEIN; POLO-LIKE KINASE-1; MITOTIC SPINDLE; AURORA-B; CONTRACTILE RING; HUMAN-CELLS; MAMMALIAN-CELLS; MIDZONE FORMATION; MEIOTIC SPINDLE;
D O I：
10.1016/j.semcdb.2010.08.005
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The central spindle is a microtubule-based structure that assembles during anaphase of mitosis in animal cells and is essential for multiple steps of cytokinesis. Central spindle assembly occurs by the cooperative action of multiple microtubule motors and modulators. Here, we review the mechanism by which the central spindle is formed, the role of several key proteins in this process and how central spindle assembly is temporally and spatially coordinated with mitosis. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：899 / 908
页数：10
相关论文
共 50 条
  • [1] MICROTUBULE ASSEMBLY IN THE MITOTIC SPINDLE
    WADSWORTH, P
    SHELDEN, E
    ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1990, 582 : 312 - 313
  • [2] The role of microtubule pivoting in spindle assembly
    Winters, L.
    Prelogovic, M.
    Pavin, N.
    Tolic, I. M.
    EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 2015, 44 : S84 - S84
  • [3] Microtubule motors in eukaryotic spindle assembly and maintenance
    Gatlin, Jesse C.
    Bloom, Kerry
    SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2010, 21 (03) : 248 - 254
  • [4] SITES OF MICROTUBULE ASSEMBLY AND DISASSEMBLY IN THE MITOTIC SPINDLE
    MITCHISON, T
    EVANS, L
    SCHULZE, E
    KIRSCHNER, M
    CELL, 1986, 45 (04) : 515 - 527
  • [5] Regulation of microtubule crosslinks during spindle assembly.
    Ismael, A.
    Aiken, J. E.
    Moore, J. K.
    MOLECULAR BIOLOGY OF THE CELL, 2017, 28
  • [6] Microtubule attachment and spindle assembly checkpoint signalling at the kinetochore
    Emily A. Foley
    Tarun M. Kapoor
    Nature Reviews Molecular Cell Biology, 2013, 14 : 25 - 37
  • [7] Microtubule nucleation for spindle assembly: one molecule at a time
    Kraus, Jodi
    Alfaro-Aco, Raymundo
    Gouveia, Bernardo
    Petry, Sabine
    TRENDS IN BIOCHEMICAL SCIENCES, 2023, 48 (09) : 761 - 775
  • [8] Microtubule attachment and spindle assembly checkpoint signalling at the kinetochore
    Foley, Emily A.
    Kapoor, Tarun M.
    NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2013, 14 (01) : 25 - 37
  • [9] Functional central spindle assembly requires de novo microtubule generation in the interchromosomal region during anaphase
    Uehara, Ryota
    Goshima, Gohta
    JOURNAL OF CELL BIOLOGY, 2010, 191 (02): : 259 - 267
  • [10] Functional Overlap of Microtubule Assembly Factors in Chromatin-Promoted Spindle Assembly
    Groen, Aaron C.
    Maresca, Thomas J.
    Gatlin, Jesse C.
    Salmon, Edward D.
    Mitchison, Timothy J.
    MOLECULAR BIOLOGY OF THE CELL, 2009, 20 (11) : 2766 - 2773
12345