Target lipidomics approach to reveal the resolution of inflammation induced by Chinese medicine combination in Liu-Shen-Wan against realgar overexposure to rats

被引：12

作者：

Wang, Jiaojiao ^{[1
]}

Ding, Lanfang ^{[4
]}

Zhou, Jing ^{[1
]}

Ma, Hongyue ^{[1
]}

Wu, Yuanyuan ^{[1
]}

Wang, Jiajia ^{[1
]}

Lv, Xiang ^{[1
]}

Liu, Shengjin ^{[1
]}

Wang, Hengbin ^{[5
]}

Yan, Yanqing ^{[5
]}

Luo, Niancui ^{[5
]}

Li, Quan ^{[5
]}

Xu, Huiqin ^{[1
]}

Di, Liuqing ^{[2
,3
]}

Wu, Qinan ^{[1
]}

Duan, Jinao ^{[1
]}

机构：

[1] Nanjing Univ Chinese Med, Jiangsu Key Lab Efficacy & Safety Evaluat TCM, Jiangsu Key Lab High Technol Res TCM Formulae, Jiangsu Collaborat Innovat Ctr Chinese Med Resour, Nanjing, Peoples R China

[2] Nanjing Univ Chinese Med, Sch Pharm, Nanjing, Peoples R China

[3] Jiangsu Prov TCM Engn Technol Res Ctr Highly Effi, Nanjing, Peoples R China

[4] Nanjing Matern & Child Hlth Care Hosp, Nanjing, Peoples R China

[5] Leiyunshang Pharmaceut Co Ltd, Suzhou, Peoples R China

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2020年 / 249卷

关键词：

Liu shen wan; Liver inflammation; Realgar; Reducing toxicity; Chinese medicine compatibility; PATHWAY;

D O I：

10.1016/j.jep.2019.112171

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Ethnopharmacological relevance: Liu-Shen-Wan (LSW) is one of the popular over-the-counter drugs in Asia, which contains realgar (As4S4), used for the treatment of upper respiratory tract inflammation and skin infections. However, the safety and potential risk of this arsenic remain unknown. Aim of the study: The aim of this study was to determine total arsenic in tissue and investigate effects of regular dose and overdose LSW exposure on rat liver. Materials and methods: We used a target lipidomics approach to quantify inflammatory eicosanoids and employed ICP-MS to determine total arsenic in tissue. Results: The results showed that oral administration of 8 and 40 mg/kg LSW (1 and 5 fold human-equivalent dose) induced light changes of liver lipidomic profile in rats, which was associated with anti-inflammatory function of LSW. In our recent report, we observed that 41 and 134 mg/kg realgar (40 and 132 fold humanequivalent dose) stimulated rat liver inflammation through up-regulation of pro-inflammatory LOX-derived, CYP-derived HETEs and COX-derived PGs. However, we found that LSW in the form of drug combination, containing 41 and 134 mg/kg realger, could not stimulate these similar inflammatory responses in rats, although the liver total arsenic levels of the realger and LSW groups were same. Conclusion: The downregulation of pro-inflammatory response showed that the LSW containing realger is safer than realger alone administrated to rats. These results suggested that Chinese medicines combination could reduce realgar-derived arsenic toxicity in rats.

引用

页数：9

共 2 条

[1] Target RNA expression omics approach to reveal the liver detoxification effect induced by Chinese medicine prescription Niu Huang Jie Du against realgar overexposure to mice
Wu, Juan
Yang, Dongqing
Song, Ziwei
Qian, Qin
Dai, Jianguo
Dong, Ju
[J]. JOURNAL OF ETHNOPHARMACOLOGY, 2022, 298
[2] Liu-Shen-Wan, a traditional Chinese medicine, improves survival in sepsis induced by cecal ligation and puncture via reducing TNF-α levels, MDA content and enhancing macrophage phagocytosis
Ma, Hongyue
Kou, Junping
Zhu, Danni
Yan, Yongqing
Yu, Boyang
[J]. INTERNATIONAL IMMUNOPHARMACOLOGY, 2006, 6 (08) : 1355 - 1362

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