GSH-resistant and highly cytoselective ruthenium(ii)-p-cymene-(imidazo[4,5-f][1,10]phenanthrolin-2-yl)phenol complexes as potential anticancer agents

被引：18

作者：

Kar, Binoy ^{[1
]}

Das, Utpal ^{[1
]}

De, Sourav ^{[1
]}

Pete, Sudhindra ^{[1
]}

Sharma, Ajay S. ^{[1
]}

Roy, Nilmadhab ^{[1
]}

Kumar, Ashok S. K. ^{[1
]}

Panda, Debashis ^{[2
]}

Paira, Priyankar ^{[1
]}

机构：

[1] Vellore Inst Technol, Sch Adv Sci, Dept Chem, Vellore 632014, Tamilnadu, India

[2] Rajiv Gandhi Inst Petr Technol, Inst Natl Importance, Dept Basic Sci & Humanities, Amethi 229304, Uttar Pradesh, India

来源：

DALTON TRANSACTIONS | 2021年 / 50卷 / 30期

关键词：

RUTHENIUM(II) COMPLEXES; ORGANOMETALLIC COMPOUNDS; IRIDIUM(III) COMPLEXES; ACTIVATION MECHANISMS; BIOLOGICAL EVALUATION; METAL-COMPLEXES; DNA; GLUTATHIONE; BINDING; DRUG;

D O I：

10.1039/d1dt01604k

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

To avoid the side effects of the current popular platinum-based anticancer drugs, researchers have made tireless attempts to design appropriate GSH-resistant Ru(ii)-arene complexes. In this regard, luminescent ruthenium(ii)-p-cymene-imidazophenanthroline complexes were developed as promising highly cytoselective cancer theraputic agents for HeLa and Caco-2 cells.

引用

页码：10369 / 10373

页数：5

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