Clinical outcome of febrile neutropenia in children with cancer using ceftazidime and aminoglycosides

被引：10

作者：

Laoprasopwattana, Kamolwish ^{[1
]}

Pruekprasert, Pornpirnol ^{[1
]}

Laosombat, Vichai ^{[1
]}

Wongchanchailert, Malai ^{[1
]}

机构：

[1] Prince Songkla Univ, Fac Med, Dept Pediat, Hat Yai 90110, Thailand

来源：

PEDIATRIC HEMATOLOGY AND ONCOLOGY | 2007年 / 24卷 / 5-8期

关键词：

aminoglycosides; ceftazidime; children; lever; neutropenia;

D O I：

10.1080/08880010701703636

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To determine treatment outcome using ceftazidime-aminoglycosides in febrile neutropenic children with cancer, the authors conducted a prospective cohort study in 216 episodes. Early and complete responses to antibiotics were 108/216 (50.0%) and 133/216 (61.6%) episodes, respectively. Death, a modification of antibiotic(s), and resistance to ceftazidime were 2/118 (1.7%), 73/216 (33.8%), and 4/216 (1.9%) episodes, respectively. Primary bacteremia and emerging bacteremia during treatment were 20/216 (9.3%) and 5/216 (2.3%) episodes. Ceftazidime-aminoglycosides was found to be a reasonable initial treatment of febrile neutropenia in the authors' institution. Imipenem is considered in patients who have clinical sepsis and who fail to respond to initial treatment.

引用

页码：595 / 606

页数：12

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