Reactive uveitis, retinal vasculitis and scleritis as ocular end-stage of Acanthamoeba keratitis: a histological study

被引：8
|
作者：
Shi, Lei [1 ,2 ]
Hager, Tobias [1 ]
Fries, Fabian Norbert [1 ]
Daas, Loay [1 ]
Holbach, Leonard [3 ]
Hofmann-Rummelt, Carmen [3 ]
Zemova, Elena [1 ]
Seitz, Berthold [1 ]
Szentmary, Nora [1 ,4 ]
机构：
[1] Saarland Univ, Med Ctr, Dept Ophthalmol, Kirrberger Str 100, D-66424 Homburg, Germany
[2] Univ Sci & Technol China, Div Life Sci & Med, Affiliated Hosp 1, Dept Ophthalmol, Hefei 230001, Anhui, Peoples R China
[3] Friedrich Alexander Univ Erlangen Nurnberg, Dept Ophthalmol, D-91052 Erlangen, Germany
[4] Semmelweis Univ, Dept Ophthalmol, H-1093 Budapest, Hungary
来源：
INTERNATIONAL JOURNAL OF OPHTHALMOLOGY | 2019年 / 12卷 / 12期
关键词：
Acanthamoeba keratitis; enucleation; uveitis; retinal vasculitis; scleritis; IRIS ATROPHY; CHORIORETINITIS; SCLEROKERATITIS; CATARACT; WALES; EYE;
D O I：
10.18240/ijo.2019.12.20
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
We analysed histologically two Acanthamoeba keratitis (AK) eyes with anterior and posterior segment inflammation and blindness. Two enucleated eyes of 2 patients (age 45 and 51y) with AK (PCR of epithelial abrasion positive) were analysed. Histological analysis was performed using hematoxylin-eosin, periodic acid-Schiff and Gomori-methenamine silver staining. We could not observe Acanthamoeba trophozoites or cysts neither in the cornea nor in other ocular tissues. Meanwhile, we found uveitis, retinal vasculitis and scleritis in these eyes, due to the long-standing, recalcitrant AK. So in this stage of AK, systemic immune suppression may be necessary for a longer time period.
引用
收藏
页码：1966 / 1971
页数：6
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