Wnt Signaling as a Potential Therapeutic Target for Frontotemporal Dementia

被引：11

作者：

Korade, Zeljka ^{[1
,2
]}

Mirnics, Karoly ^{[1
,2
]}

机构：

[1] Vanderbilt Univ, Dept Psychiat, Nashville, TN 37232 USA

[2] Vanderbilt Univ, Vanderbilt Kennedy Ctr Res Human Dev, Nashville, TN 37232 USA

来源：

NEURON | 2011年 / 71卷 / 06期

关键词：

DRUG DISCOVERY; PROGRANULIN; MUTATIONS; PATHWAY; MICE;

D O I：

10.1016/j.neuron.2011.09.002

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Progranulin mutations result in frontotemporal dementia, but the underlying pathophysiology has remained largely unexplained. New data by Geschwind and colleagues in this issue of Neuron uncovered that the Wnt/FZD2 signaling pathway is an early and critical contributor to disease pathology.

引用

页码：955 / 957

页数：3

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