Enzymatic resolution of 2,2,2-trifluoro-1-(1-pyrenyl)ethanol with lipases

被引：8
|
作者：
Kato, K
Katayama, M
Fujii, S
Kimoto, H
机构：
[1] Department of Chemistry, National Industrial Research Institute of Nagoya, Nagoya, Hirate-cho, Kita-ku
来源：
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1997年 / 61卷 / 01期
关键词：
lipase; enantioselective alcoholysis; enzymatic resolution; CATALYZED OPTICAL RESOLUTION; ACYLATION;
D O I：
10.1271/bbb.61.194
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The optical resolution of (+/-)-2,2,2-trifluoro-1-(1-pyrenyl)ethanol was achieved by using lipases. In particular, Pseudomonas aeruginosa lipase (lipase LIP) showed high enantioselectivity (E = > 100) and reactivity in the alcoholysis of the chloroacetyl ester of the title compound, The reactivity of the lipase LIP-catalyzed enantioselective alcoholysis of the chloroacetate with 1-hexanol was much higher than that of the acetylating the alcohol with vinyl acetate.
引用
收藏
页码：194 / 196
页数：3
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