Efficient two-step synthesis of structurally diverse indolo[2,3-b]quinoline derivatives

被引：18

作者：

Kundal, Sandip ^{[1
]}

Chakraborty, Baitan ^{[1
]}

Paul, Kartick ^{[1
]}

Jana, Umasish ^{[1
]}

机构：

[1] Jadavpur Univ, Dept Chem, Kolkata 700032, W Bengal, India

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2019年 / 17卷 / 09期

关键词：

DEHYDROGENATIVE-COUPLING CDC; C-H AMINATION; IN-VITRO; INDOLOQUINOLINE ALKALOIDS; ANTIPLASMODIAL ACTIVITY; BOND FORMATION; CRYPTOLEPINE; INDOLES; NEOCRYPTOLEPINES; CYCLIZATION;

D O I：

10.1039/c8ob03033b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A general and efficient synthesis of diverse tetracyclic indolo [2,3-b] quinoline derivatives was achieved through palladium-catalyzed domino carboannulation/cross-coupling and DDQ-mediated double cross-dehydrogenative C-N bond formation. This approach provides a straightforward, atom-economical and concise route to easily access a diverse range of tetracyclic indolo [2,3-b] quinolines and their analogues in excellent yields with good tolerance of functional groups.

引用

页码：2321 / 2325

页数：5

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