Consideration of the role of gender in alcohol tobacco, and drug use,for the most part has been omitted from studies of intervention effectiveness. Consequently, although scientists now can state with confidence that effective prevention approaches exist, it is not clear whether those programs are effective specifically for girls. Consequently although great strides have been made in identifying substance use patterns, precursors to use and effective prevention strategies ill general, many questions remain about the ways in which those prevention efforts might address better the need; of differing gender and racial/ethnic groups. The primary goal for this report was first to review evidence of the effectiveness of traditional alcohol tobacco, and drug use prevention approaches with girls and with bays, as well as available evidence from gender-specific or gender informed interventions focused specifically an girls, and second, to make recommendations regarding needed research and prevention strategies that rake gender into account.