Objective: To explore the effect of continuous home nursing visits on patients with chronic renal failure and peritoneal dialysis. Methods: Seventy-two patients with chronic renal failure and peritoneal dialysis were selected. According to a random number table, they were divided into an observation group and a control group, with 36 cases in each group. The patients in the control group received telephone follow-up, and the patients in the observation group underwent continuous home nursing visits. The dialysis adequacy, mental states of anxiety and depression, quality of life, nutritional status, and complications were compared between the two groups. Results: The serum creatinine (SCr) and blood urea nitrogen (BUN) levels in the observation group were lower than those of control group after nursing (both P<0.05). The residual glomerular filtration rate (rGFR) in the observation group showed no statistical significance before and after nursing (P<0.05). The anxiety and depression scores in the observation group were lower than those of control group after the nursing (P<0.001). The physical function, emotional function, role function, cognitive function, social function, and overall quality of life scores increased in the observation group after the nursing, and they were higher than those of the control group (all P<0.001). The prealbumin (PA), hemoglobin (Hb), and albumin (ALB) levels increased in the observation group after the nursing (P<0.05), but the corresponding values in the control group showed no obvious changes (P<0.05). The nutritional indexes in the observation group were higher than those of the control group (P<0.01). The overall complication rate in the observation group (16.67%) was lower than it was in the control group (38.89%) (P<0.05). Conclusion: The application of continuous home nursing visits for patients with chronic renal failure and peritoneal dialysis can improve the dialysis adequacy, the patient's psychological state, quality of life and nutritional status, and reduce complications. It is worthy of clinical promotion.