Genetic characteristics of HIV-1 CRF06_cpx and CRF56_cpx strains isolated in Guangzhou, China

被引：0

作者：

Lan, Yun ^{[1
]}

Li, Linghua ^{[1
]}

Cai, Weiping ^{[1
]}

Li, Junbin ^{[1
]}

Deng, Xizi ^{[1
]}

Li, Feng ^{[1
]}

Lei, Chunliang ^{[1
]}

Hu, Fengyu ^{[1
]}

Tang, Xiaoping ^{[1
]}

机构：

[1] Guangzhou Med Univ, Guangzhou Peoples Hosp 8, 627 Dongfeng East Rd, Guangzhou 510060, Peoples R China

来源：

ARCHIVES OF VIROLOGY | 2021年 / 166卷 / 10期

关键词：

CIRCULATING RECOMBINANT FORM; HIGH PREVALENCE; SUBTYPES; RESISTANCE; DIVERSITY;

D O I：

10.1007/s00705-021-05198-5

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Strains of the HIV-1 circulating recombinant forms (CRFs) 06_cpx and 56_cpx were identified for the first time in Guangzhou, China. The nearly full-length genome (NFLG) sequence was amplified, and the PCR products were sequenced by the Sanger method. The CRF06_cpx and CRF56_cpx strains were identified using the Basic Local Alignment Search Tool (BLAST) and confirmed by neighbour-joining (NJ) phylogenetic analysis. Additionally, these strains were found to contain transmitted drug resistance mutations that have little effect on first-line efavirenz (EFV)-based treatment. Genetic analysis of the detailed sequence data will provide more information on the HIV-1 epidemic in China.

引用

页码：2853 / 2857

页数：5

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