Synthesis and antimicrobial activity of 1-[(substituted carbamoyl)amino]-1H,3H-1λ5-[1,3,2]oxazaphospholo[3,4-a] benzimidazol-1-ones

被引：2
|
作者：
Anasuyamma, U.
Haranath, P.
Kumar, M. Anil
Reddy, C. Suresh [1 ]
Raju, C. Naga
机构：
[1] Sri Venkateswara Univ, Coll Engn, Dept Chem, Tirupati 517502, Andhra Pradesh, India
[2] Univ Murcia, Dept Organ Chem, Murcia, Spain
来源：
SYNTHETIC COMMUNICATIONS | 2007年 / 37卷 / 19-21期
关键词：
carbamido phosphoric acid dichloride; isocyanatophosphonic dichloride; oxazaphosphospholo benzimidazols;
D O I：
10.1080/00397910701483886
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
1-[(Substituted carbamoyl)amino]-1H,3H-1 lambda(5) -[1,3,2]oxazaphospholo[3,4-a] benzimidazol-l-ones were synthesized by reacting benzimidazole 2-methanol (4) with different chlorides of carbamidophosphoric acids (3) in the presence of triethylamine at 40-45 degrees C. Their H-1, C-13, and P-31 NMR spectral data were discussed. The title compounds were tested for their activity against the fungi Aspergillus niger and Fusarium solani and bacteria Staphylococcus aureus and Escherichia coli. These compounds showed moderate antibacterial activity when compared with antifungal activity.
引用
收藏
页码：3429 / 3437
页数：9
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