Width of the third ventricle assessed by transcranial sonography can monitor brain atrophy in a time- and cost-effective manner - Results from a longitudinal study on 500 subjects

被引：33

作者：

Wollenweber, Frank Arne ^{[1
,2
]}

Schomburg, Robert ^{[2
]}

Probst, Mareike ^{[2
]}

Schneider, Vera ^{[2
]}

Hiry, Teresa ^{[2
]}

Ochsenfeld, Annika ^{[2
]}

Mueller, Martin ^{[3
]}

Dillmann, Ulrich ^{[2
]}

Fassbender, Klaus ^{[2
]}

Behnke, Stefanie ^{[2
]}

机构：

[1] Rhein Westfal TH Aachen, Dept Psychiat & Psychotherapy, D-52074 Aachen, Germany

[2] Univ Saarland, Dept Neurol, D-66421 Homburg Saar, Germany

[3] Kantonsspital Luzern, Dept Neurol, CH-6000 Luzern 16, Switzerland

来源：

PSYCHIATRY RESEARCH-NEUROIMAGING | 2011年 / 191卷 / 03期

关键词：

Cognitive decline; Screening; Neuroimaging; ALZHEIMERS-DISEASE; MULTIPLE-SCLEROSIS; VENTRICULAR ENLARGEMENT; COGNITIVE DYSFUNCTION; VASCULAR DEMENTIA; LEWY BODIES; SERIAL MRI; PROGRESSION; DIAMETER; AD;

D O I：

10.1016/j.pscychresns.2010.09.010

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Ventricular width and its enlargement over time are discussed as promising markers for preclinical brain atrophy. The aim of our study was to define whether brain atrophy can reliably be monitored by transcranial ultrasound (TCS). In a prospective longitudinal trial over 5 years, 500 healthy persons were examined by a standardized protocol with TCS in addition to an extensive cognitive testing using the Consortium to Establish a Registry of Alzheimer's Disease Neuropsychological Testing (CERAD-NP). TCS displayed the third ventricle in 96% of all cases at the follow-up with a high intra-individual reproducibility and excellent inter-rater coefficient (0.992). The mean diameter of the third ventricle in subjects with a cognitive decline was significantly wider (6 mm +/- 2) than in subjects with normal cognitive testing results (4.6 mm +/- 1.8). We demonstrated that the width of the third ventricle, as a marker of brain atrophy can reliably be monitored by using TCS as a non-invasive, time- and cost-effective method. We provide evidence that the assessed width of the third ventricle can differentiate between subjects with a normal cognitive performance and subjects with a cognitive decline. TCS may be a useful screening tool in the early diagnosis of cognitive decline. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

引用

页码：212 / 216

页数：5