Past, present and future of atomic force microscopy in life sciences and medicine

被引：139

作者：

Parot, Pierre ^{[1
]}

Dufrene, Yves F. ^{[2
]}

Hinterdorfer, Peter ^{[3
]}

Le Grimellee, Christian ^{[4
,5
]}

Navajas, Daniel ^{[6
]}

Pellequer, Jean-Luc ^{[1
]}

Scheuring, Simon ^{[7
]}

机构：

[1] CEA VALRHO, Ctr Marcoule,Lab Interact & Reconnaissance Mol, DSV iBEB SBTN LIRM, Serv Biochim & Toxicol Nucl, F-30207 Bagnols Sur Ceze, France

[2] Catholic Univ Louvain, B-1348 Louvain, Belgium

[3] Johannes Kepler Univ Linz, A-4040 Linz, Austria

[4] Inst Natl Sante & Rech Med, Unite 554, Montpellier, France

[5] Univ Montpellier, Montpellier, France

[6] Univ Barcelona, IDIBAPS & CIBER Enfermaedades Resp, Barcelona, Spain

[7] Inst Curie, Paris, France

来源：

JOURNAL OF MOLECULAR RECOGNITION | 2007年 / 20卷 / 06期

关键词：

AFM; cell imaging; cell mechanics; cell adhesion; DFS; single molecules; high speed imaging; membrane protein imaging; high resolution imaging; protein and membrane imaging;

D O I：

10.1002/jmr.857

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To introduce this special issue of the Journal of Molecular Recognition dedicated to the applications of atomic force microscopy (AFM) in life sciences, this paper presents a short summary of the history of AFM in biology. Based on contributions from the first international conference of AFM in biological sciences and medicine (AFM BioMed Barcelona, 19-21 April 2007), we present and discuss recent progress made using AFM for studying cells and cellular interactions, probing single molecules, imaging biosurfaces at high resolution and investigating model membranes and their interactions. Future prospects in these different fields are also highlighted. Copyright (c) 2007 John Wiley & Sons, Ltd.

引用

页码：418 / 431

页数：14

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