Biaryl Ketones by Suzuki-Miyaura Cross-Coupling of Organotrifluoroborates and Acyl Chlorides

被引：14
|
作者：
Forbes, Alaina M. [1 ]
Meier, G. Patrick [2 ]
Jones-Mensah, Ebenezer [1 ]
Magolan, Jakob [1 ]
机构：
[1] Univ Idaho, Dept Chem, Moscow, ID 83844 USA
[2] Washington State Univ, Dept Chem, Pullman, WA 99164 USA
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 2016卷 / 17期
关键词：
Cross-coupling; Ketones; Borates; Palladium; ARYLBORONIC ACIDS; AROMATIC KETONES; ANIONIC BASES; ARYL; MECHANISM;
D O I：
10.1002/ejoc.201600199
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A procedure for the synthesis of biaryl ketones by a palladium-catalyzed Suzuki-Miyaura cross-coupling reaction between phenyltrifluoroborates and benzoyl chlorides is described. Organotrifluoroborates are unique to other cross-coupling reagents as they have a high functional-group tolerance and are moisture-stable. Moderate to excellent yields were obtained for all substrates tested.
引用
收藏
页码：2983 / 2987
页数：5
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