Effect of treatment duration on plasma levels of clozapine and N-desmethylclozapine in men and women

被引：21

作者：

Fabrazzo, M

Esposito, G

Fusco, R

Maj, M

机构：

[1] Department of Psychiatry, First Medical School, University of Naples, I-80138 Napoli, Largo Madonna delle Grazie

来源：

PSYCHOPHARMACOLOGY | 1996年 / 124卷 / 1-2期

关键词：

clozapine; N-desmethylclozapine; clozapine-N-oxide; sex; plasma levels;

D O I：

10.1007/BF02245621

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Plasma levels of clozapine and its major metabolites, N-desmethylclozapine and clozapine-N-oxide, were measured in 18 schizophrenic patients at different times (4, 6 and 24 weeks) during the course of treatment with multiple doses of the drug, by using high performance liquid chromatography (HPLC) with UV detection. Plasma levels of clozapine and N-desmethylclozapine were significantly higher in females than in males after 4 and 6 weeks, but not after 24 weeks, of treatment. No sex difference was found at any time with respect to plasma levels of clozapine-N-oxide.

引用

页码：197 / 200

页数：4

共 50 条

[1] Assessment of Genetic and Lifestyle Factors on Clozapine and N-desmethylclozapine Plasma Levels in Schizophrenia Patients
Demirbugen, Oz M.
Ozdemir, F.
Tok, K. C.
Dural, E.
Kir, Y.
Ulusoy, M.
Gumustas, M.
Baskak, B.
Suzen, H. S.
[J]. PHARMACOPSYCHIATRY, 2024, 57 (02) : 87 - 87
[2] Cognition and Plasma Ratio of Clozapine to N-desmethylclozapine in Patients With Clozapine-Resistant Schizophrenia
Thornton, Allen E.
Procyshyn, Ric M.
Barr, Alasdair M.
MacEwan, G. William
Honer, William G.
[J]. AMERICAN JOURNAL OF PSYCHIATRY, 2015, 172 (12): : 1259 - 1259
[3] Effect of Cigarette Smoking on Clozapine Dose and on Plasma Clozapine and N-Desmethylclozapine (Norclozapine) Concentrations in Clinical Practice
Flanagan, Robert James
Hunter, Samora
Obee, Stephen John
[J]. JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, 2023, 43 (06) : 514 - 519
[4] N-DESMETHYLCLOZAPINE - A CLOZAPINE METABOLITE THAT SUPPRESSES HEMATOPOIESIS
GERSON, SL
ARCE, C
MELTZER, HY
[J]. BRITISH JOURNAL OF HAEMATOLOGY, 1994, 86 (03) : 555 - 561
[5] Plasma Clozapine and N-Desmethylclozapine (Norclozapine) Concentrations and the Clozapine/Norclozapine Ratio: Effect of Dose, Sex, and Cigarette Smoking
Flanagan, Robert James
Obee, Stephen John
Kim, Alice Hyun Min
Every-Palmer, Susanna
[J]. JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, 2024, 44 (05) : 492 - 501
[6] Therapeutic monitoring of plasma clozapine and N-desmethylclozapine (norclozapine): practical considerations
Flanagan, Robert J.
Gee, Siobhan
Belsey, Sarah
Couchman, Lewis
Lally, John
[J]. BJPSYCH ADVANCES, 2023, 29 (02) : 92 - 102
[7] Prediction of Working Memory Performance in Schizophrenia by Plasma Ratio of Clozapine to N-Desmethylclozapine
Rajji, Tarek K.
Mulsant, Benoit H.
Davies, Simon
Lache, Sawsan M. Ka
Tsoutsoulas, Christopher
Pollock, Bruce G.
Remington, Gary
[J]. AMERICAN JOURNAL OF PSYCHIATRY, 2015, 172 (06): : 579 - 585
[8] Prediction of cognitive performance in treatment-resistant psychotic patients by plasma ratio of clozapine to N-desmethylclozapine
Molins, C.
Carceller-Sindreu, M.
Portella, M. J.
Navarro, H.
Carmona, C.
Pineiro, M.
Martinez, E.
Alvarez, E.
[J]. EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2016, 26 : S566 - S567
[9] Impact of Clozapine, N-Desmethylclozapine and Chlorpromazine on Thromboxane Production in Vitro
Himmerich, Hubertus
Schmidt, Luise
Becker, Susen
Kortz, Linda
Schoenherr, Jeremias
Mergl, Roland
Bauer, Katrin
Sack, Ulrich
Sheldrick, Abigail J.
Thiery, Joachim
Ceglarek, Uta
[J]. MEDICINAL CHEMISTRY, 2012, 8 (06): : 1032 - 1038
[10] Relationship of Change in Plasma Clozapine/N-desmethylclozapine Ratio with Cognitive Performance in Patients with Schizophrenia
Park, Royun
Kim, Seoyoung
Kim, Euitae
[J]. PSYCHIATRY INVESTIGATION, 2020, 17 (11) : 1158 - 1165

← 1 2 3 4 5 →