p53 is not necessary for nuclear translocation of GAPDH during NO-induced apoptosis

被引：3

作者：

Kim, Jum-Ji ^{[1
]}

Lee, Mi-Young ^{[1
]}

机构：

[1] Soonchunhyang Univ, Dept Med Biotechnol, Asan 336600, South Korea

来源：

BMB REPORTS | 2011年 / 44卷 / 12期

关键词：

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH); Hepatoma cells; Nuclear translocation; p53; S-nitrosoglutathione (GSNO); OXIDE-INDUCED APOPTOSIS; DIFFERENTIALLY EXPRESSED PROTEINS; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE; NITRIC-OXIDE; CELL-DEATH; S-NITROSOGLUTATHIONE; GLYCOLYTIC PROTEIN; SIGNALING PATHWAYS; MAMMALIAN-CELLS; OVEREXPRESSION;

D O I：

10.5483/BMBRep.2011.44.12.782

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Aberrant GAPDH expression following S-nitrosoglutathione (GSNO) treatment was compared in HepG2 cells, which express functional p53, and Hep313 cells, which lack functional p53. The results of Western blotting and fluorescent immunocytochemistry revealed that nuclear translocation and accumulation of GAPDH occur in both HepG2 and Hep3B cells. This finding suggests that p53 may not be necessary for the GSNO-induced translocation of GAPDH to the nucleus during apoptotic cell death in hepatoma cells. [BMB reports 2011; 44(12): 782-786]

引用

页码：782 / 786

页数：5

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