Asymmetric Construction of Highly Functionalized Spirobarbiturate-Cyclopentenes through Chiral Phosphine-Catalyzed [3+2] Annulation of Morita-Baylis-Hillman Carbonates with Barbiturate-Derived Alkenes

被引：52

作者：

Liu, Yang ^{[1
]}

Yang, Wenjun ^{[1
]}

Wu, Yang ^{[1
]}

Mao, Biming ^{[1
]}

Gao, Xing ^{[1
]}

Liu, Honglei ^{[1
]}

Sun, Zhanhu ^{[1
]}

Xiao, Yumei ^{[1
]}

Guo, Hongchao ^{[1
]}

机构：

[1] China Agr Univ, Dept Appl Chem, 2 West Yuanmingyuan Rd, Beijing 100193, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2016年 / 358卷 / 18期

基金：

高等学校博士学科点专项科研基金;

关键词：

alkenes; allenoates; annulation; phosphines; spirobarbiturates; ENANTIOSELECTIVE TOTAL-SYNTHESIS; C; N-CYCLIC AZOMETHINE IMINES; ELECTRON-DEFICIENT ALKENES; DIPEPTIDE-BASED PHOSPHINES; CYCLOADDITION REACTIONS; ACTIVATED OLEFINS; ACID; DERIVATIVES; ALLENOATES; ALLENES;

D O I：

10.1002/adsc.201600450

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A multifunctional chiral phosphine-catalyzed enantioselective [3+2] annulation of Morita-Baylis-Hillman carbonates with barbiturate-derived alkenes has been achieved under mild conditions, providing a variety of chiral spirobarbiturate-cyclopentenes in moderate to excellent yields with moderate to excellent diastereo- and enantioselectivities.

引用

页码：2867 / 2872

页数：6

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