Nanotechnology and aptamers: applications in drug delivery

被引：199
|
作者：
Levy-Nissenbaum, Etgar [1 ,3 ,5 ]
Radovic-Moreno, Aleksandar F. [3 ,4 ,5 ]
Wang, Andrew Z. [1 ,2 ,5 ]
Langer, Robert [3 ,4 ,5 ]
Farokhzad, Omid C. [1 ,5 ]
机构：
[1] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Anesthesiol,Lab Nanomed & Biomat, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Radiat Oncol, Boston, MA 02115 USA
[3] MIT, Dept Chem Engn, Cambridge, MA 02139 USA
[4] Harvard Univ, MIT, Div Hlth Sci & Technol, Cambridge, MA 02139 USA
[5] Harvard Univ, MIT, Ctr Canc Nanotechnol Excellence, Cambridge, MA 02139 USA
来源：
TRENDS IN BIOTECHNOLOGY | 2008年 / 26卷 / 08期
关键词：
D O I：
10.1016/j.tibtech.2008.04.006
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Nucleic acid ligands, also known as aptamers, are a class of macromolecules that are being used in several novel nanobiornedical applications. Aptamers are characterized by high affinity and specificity for their target, a versatile selection process, ease of chemical synthesis and a small physical size, which collectively make them attractive molecules for targeting diseases or as therapeutics. These properties will enable aptanners to facilitate innovative new nanotechnologies with applications in medicine. In this review, we will highlight recent developments in using aptamers in nanotechnology solutions for treating and diagnosing disease.
引用
收藏
页码：442 / 449
页数：8
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