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Association of TLR polymorphisms with bronchopulmonary dysplasia

被引：9
|
作者：
Malash, Amr Hosny [1 ]
Ali, Aliaa Adel [1 ]
Samy, Rania Mohamed [2 ]
Shamma, Radwa Ahmed [1 ]
机构：
[1] Cairo Univ, Dept Pediat, Fac Med, Cairo, Egypt
[2] Cairo Univ, Fac Med, Clin Pathol, Cairo, Egypt
来源：
GENE | 2016年 / 592卷 / 01期
关键词：
Bronchopulmonary dysplasia; Toll-like receptors; Preterm neonates; Oxygen therapy; Sepsis; Neonatal mortality; TOLL-LIKE RECEPTORS; GENETIC SUSCEPTIBILITY; RECOGNITION; EXPRESSION; FLAGELLIN; PRETERM;
D O I：
10.1016/j.gene.2016.07.049
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Background: Bronchopulmonary dysplasia (BPD) remains a leading cause of morbidity and mortality during infancy. Evidence suggests that the Toll-like receptor (TLR) signaling pathway plays an integral role in lung inflammation and injury. This study aimed to detect single nucleotide polymorphisms (SNPs) in TLR pathway genes [TLR5 and Toll-interleukin 1 receptor domain-containing adaptor protein (TIRAP)] among preterm neonates and to determine their association with the development and severity of bronchopulmonary dysplasia. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：23 / 28
页数：6
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