Heterotrimeric G protein activation by G-protein-coupled receptors

被引：796
|
作者：
Oldham, William M. [1 ]
Hamm, Heidi E. [1 ]
机构：
[1] Vanderbilt Univ, Dept Pharmacol, Sch Med, Nashville, TN 37232 USA
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2008年 / 9卷 / 01期
关键词：
D O I：
10.1038/nrm2299
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Heterotrimeric G proteins have a crucial role as molecular switches in signal transduction pathways mediated by G-protein-coupled receptors. Extracellular stimuli activate these receptors, which then catalyse GTP-GDP exchange on the G protein alpha-subunit. The complex series of interactions and conformational changes that connect agonist binding to G protein activation raise various interesting questions about the structure, biomechanics, kinetics and specificity of signal transduction across the plasma membrane.
引用
收藏
页码：60 / 71
页数：12
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