The role of decorin in cardiovascular diseases: more than just a decoration

被引：17

作者：

Thu Thi Vu ^{[1
,5
]}

Marquez, Jubert ^{[2
,3
]}

Long Thanh Le ^{[2
,3
]}

Anh Thi Tuyet Nguyen ^{[2
,3
]}

Kim, Hyoung Kyu ^{[2
,3
,4
]}

Han, Jin ^{[2
,3
]}

机构：

[1] VNU Univ Sci, Natl Key Lab Enzyme & Prot Technol, Fac Biol, Hanoi, Vietnam

[2] Inje Univ, Natl Res Lab Mitochondrial Signaling, Cardiovasc & Metab Dis Ctr, Dept Physiol,BK21 Plus Project Team,Coll Med, Busan, South Korea

[3] Inje Univ, Natl Res Lab Mitochondrial Signaling, Dept Hlth Sci & Technol,Coll Med, BK21 Plus Project Team,Cardiovasc & Metab Dis Ctr, Busan, South Korea

[4] Inje Univ, Coll Med, Dept Integrated Biomed Sci, Busan, South Korea

[5] Dinh Tien Hoang Inst Med, Div Stroke & Cardiovasc Dis, Hanoi, Vietnam

来源：

FREE RADICAL RESEARCH | 2018年 / 52卷 / 11-12期

基金：

新加坡国家研究基金会;

关键词：

Cardiovascular disease; decorin; heart failure; mitochondria; GROWTH-FACTOR-BETA; MITOCHONDRIAL OXIDATIVE-PHOSPHORYLATION; EXTRACELLULAR-MATRIX; GENE-EXPRESSION; DOWN-REGULATION; MESSENGER-RNA; TGF-BETA; MYOCARDIAL-INFARCTION; FIBRILLAR COLLAGEN; REPERFUSION INJURY;

D O I：

10.1080/10715762.2018.1516285

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Decorin (DCN) is a proteoglycan constituent of the extracellular matrix (ECM) possessing powerful antifibrotic, anti-inflammation, antioxidant, and antiangiogenic properties. By attaching to receptors in the cell surface or to several ECM molecules, it regulates plenty of cellular functions, consequently influencing cell differentiation, proliferation, and apoptosis. These processes are dependent on cell types, biological contexts, and interfere with pathological processes such as cardiovascular diseases. In this review, we briefly discuss the potential of DCN targeting in addressing cardiovascular diseases (CVD). We dive into its interactome and discuss how its interaction with the proteins can affect disease progression, and how DCN can be a possible target for CVD therapeutics.

引用

页码：1210 / 1219

页数：10

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