Synthetic studies of callyspongiolide: synthesis of the macrolactone core of the molecule

被引：14

作者：

Athe, Sudhakar ^{[1
]}

Sharma, Ashish ^{[1
]}

Marumudi, Kanakaraju ^{[2
]}

Ghosh, Subhash ^{[1
]}

机构：

[1] Indian Inst Chem Technol, CSIR, Organ & Biomol Chem Div, Hyderabad 500007, Andhra Pradesh, India

[2] Indian Inst Chem Technol, CSIR, Ctr NMR & Struct Chem, Hyderabad 500007, Andhra Pradesh, India

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2016年 / 14卷 / 28期

关键词：

RING; EFFICIENT; ALCOHOLS; ACID;

D O I：

10.1039/c6ob01007e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A concise synthetic strategy has been developed for the synthesis of the macrolactone core 2 of a unique polyketide callyspongiolide 1. The key features of the strategy included an Evan's asymmetric alkylation, diastereoselective Michael type alkylation, Brown's asymmetric allylation reaction, an allylic alkylation of an activated Z-allylic alcohol and an intramolecular Z-selective intramolecular H-W-E olefination.

引用

页码：6769 / 6779

页数：11

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