Diastereoselective Synthesis of Diketopiperazine Bis-α,β-epoxides

被引：14

作者：

Ando, Shin ^{[1
]}

Grote, Amy L. ^{[1
]}

Koide, Kazunori ^{[1
]}

机构：

[1] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2011年 / 76卷 / 04期

基金：

美国国家卫生研究院;

关键词：

ELECTRONIC-STRUCTURE; BIOLOGICAL-ACTIVITY; DERIVATIVES; EPIDITHIODIOXOPIPERAZINES; PIPERAZINE-2,5-DIONES; CHEMISTRY; PEPTIDES; MPC1001; ANALOGS;

D O I：

10.1021/jo102096d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Functionalized diketopiperazines (dioxopiperazines) are an important class of molecules in medicinal chemistry and material science. Herein we report a diastereoselective synthesis of diketopiperazine bis-alpha,beta-epoxides via the oxidation of exocyclic olefins. Although six diastereomers may be formed by this approach, only one or two of them were observed.

引用

页码：1155 / 1158

页数：4

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