Muckle-Wells syndrome

Muckle-Wells syndrome (MWS) is a rare autosomal dominant autoinflammatory disorder mainly characterized by recurrent fever, associated with urticaria and amyloidosis, as well as sensorineural deafness, arthritis and other inflammatory symptoms. Muckle-Wells disease starts at a very young age and can progress to renal failure due to generalized amyloidosis. Although there is currently no cure for MWS, novel targeted approaches hold promise as future effective therapies.