Flavonoids from the seeds of Psoralea corylifolia inhibit diacylglycerol acyltransferase

被引：6

作者：

Zhao, Yi-Ming ^{[1
]}

Xiu, Meng-Xue ^{[1
]}

Wang, Dong ^{[1
]}

Zhang, Yue ^{[1
]}

Zhang, Xin-Yu ^{[1
]}

Shao, Xiao-Jing ^{[1
]}

Wang, Xue-Hui ^{[1
]}

Lee, Hyun-Sun ^{[2
]}

Cui, Long ^{[1
]}

机构：

[1] Beihua Univ, Coll Pharm, Jilin 132013, Jilin, Peoples R China

[2] Korea Res Inst Biosci & Biotechnol, Mol Canc Res Ctr, 685-1 Yangcheongri,Ochangeup,Cheongwongun, Chungbuk 363883, South Korea

来源：

PHYTOCHEMISTRY LETTERS | 2021年 / 44卷

关键词：

Psoralea corylifolia; Aurone; Flavanone; DGAT inhibitor; CONSTITUENTS; AURONE; MEROTERPENES; DERIVATIVES; ROOT;

D O I：

10.1016/j.phytol.2021.06.013

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new flavonoids, including a new prenylated aurone, 7,2',5'-trihydroxy-8-prenylaumne (1), and two new flavanones, 2(S)-4'-hydroxy-6-methoxy-7-(2 ''-hydroxy-3 ''-methybult-3 ''-enyl)flavanone (2) and 2(S)-4'-hydroxy-7-methoxy-6-(1 '',2 ''-epoxy-3 ''-hydroxy-dimethyl)flavanone (3), together with eight known flavonoids were isolated from the seeds of Psoralea corylifolia L. The structures were elucidated by detailed spectroscopic analysis and comparison with reported data. Among them, compounds 1 - 3, 10 and 11 exhibited inhibitory effects on the enzyme activity of DGAT1 in an in vitro assay with IC50 values ranging from 52.2 +/- 1.2-89.2 +/- 1.4 mu M.

引用

页码：120 / 124

页数：5

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