New developments in telomere length analysis

被引：86
|
作者：
Baird, DM [1 ]
机构：
[1] Univ Cardiff Wales, Dept Pathol, Cardiff CF14 4XN, S Glam, Wales
来源：
EXPERIMENTAL GERONTOLOGY | 2005年 / 40卷 / 05期
关键词：
telomerase activity; tumour progression; Q-FISH;
D O I：
10.1016/j.exger.2005.02.008
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Telomeres provide an essential 'capping' function, which prevents the natural end of a chromosome from being recognised as a simple dsDNA break. The biology of human telomeres is inextricably linked with both cancer and ageing. As such there is considerable interest in determining the length of these essential and dynamic structures. Here I review, from the standpoint of ageing research in humans, the current situation with regards to technologies available to determine telomere length in human cells and tissues. (c) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码：363 / 368
页数：6
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