Neutral mononuclear dioxomolybdenum(VI) and dioxouranium(VI) complexes of oxolinic acid: Characterization and biological evaluation

被引：36

作者：

Tarushi, Alketa ^{[1
]}

Efthimiadou, Eleni K. ^{[1
]}

Christofis, Petros ^{[1
]}

Psomas, George ^{[1
]}

机构：

[1] Demokritos Natl Ctr Sci Res, Inst Phys Chem, GR-15310 Athens, Greece

来源：

INORGANICA CHIMICA ACTA | 2007年 / 360卷 / 14期

关键词：

quinolones; oxolinic acid; dioxomolybdenum(VI) complexes; uranyl(VI) complexes; interaction with calf-thymus DNA; MIC;

D O I：

10.1016/j.ica.2007.05.041

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The interaction of the first-generation quinolone antibacterial drug oxolinic acid (Hoxo) with the dioxomolybdenum(VI) and dioxouranim(VI) ions leads to the formation of the neutral mononuclear complexes MoO2(oxo)(2) and UO2(oxo)(2), respectively. The structure of the complexes has been characterized physicochemically and spectroscopically. The lowest energy model structure of the complexes has been determined with molecular modeling calculations. The antimicrobial activity of the complexes has been evaluated against three different microorganisms. The interaction of the complexes with calf-thymus DNA has been investigated with electronic and circular dichroism spectroscopies. (c) 2007 Elsevier B.V. All rights reserved.

引用

页码：3978 / 3986

页数：9

共 50 条

[1] Dioxomolybdenum(VI) and dioxouranium(VI) complexes of tetradentate amidate ligands
Maurya, MR
Singh, N
[J]. INDIAN JOURNAL OF CHEMISTRY SECTION A-INORGANIC BIO-INORGANIC PHYSICAL THEORETICAL & ANALYTICAL CHEMISTRY, 2004, 43 (03): : 542 - 547
[2] Synthesis and characterization of peroxo complexes of dioxomolybdenum(VI) and dioxouranium(VI) ions with tetraazamacrocylic ligands
Tarafder, MTH
Khan, AR
[J]. INDIAN JOURNAL OF CHEMISTRY SECTION A-INORGANIC BIO-INORGANIC PHYSICAL THEORETICAL & ANALYTICAL CHEMISTRY, 1996, 35 (09): : 781 - 783
[3] Spectral and biological studies of Dioxouranium(VI), dioxomolybdenum(VI), oxovanadium(II) complexes of o-hydroxy acetophenone oxime
Mehta, BH
Syed, FF
[J]. ASIAN JOURNAL OF CHEMISTRY, 2002, 14 (3-4) : 1631 - 1634
[4] COMPLEXES OF DIOXOURANIUM(VI) WITH PHENYLACETOHYDROXAMIC ACID
KUNDU, PC
DAS, CR
[J]. INDIAN JOURNAL OF CHEMISTRY SECTION A-INORGANIC BIO-INORGANIC PHYSICAL THEORETICAL & ANALYTICAL CHEMISTRY, 1983, 22 (10): : 901 - 903
[5] COMPLEXES OF DIOXOURANIUM(VI) WITH BENZHYDROXAMIC ACID
KUNDU, PC
BHATTACHERJYA, S
[J]. INDIAN JOURNAL OF CHEMISTRY SECTION A-INORGANIC BIO-INORGANIC PHYSICAL THEORETICAL & ANALYTICAL CHEMISTRY, 1980, 19 (03): : 233 - 235
[6] SYNTHESIS AND CHARACTERIZATION OF NEW DIOXOURANIUM(VI) COMPLEXES OF ACID HYDRAZIDES
MAKI, AKT
YACOUTANOUR, A
MOSTAFA, MM
[J]. JOURNAL OF THE INDIAN CHEMICAL SOCIETY, 1995, 72 (07) : 447 - 451
[7] Dioxomolybdenum(VI) complexes as catalytic neutral esterification agents
Nag, P
Bohra, R
Mehrotra, RC
[J]. JOURNAL OF CHEMICAL RESEARCH-S, 2002, (02): : 86 - 88
[8] Synthesis, characterization and biological activity of dioxouranium(VI) complexes of acyldipyridoxal hydrazones
Yang, CT
Ranford, JD
Vittal, JJ
[J]. SYNTHESIS AND REACTIVITY IN INORGANIC METAL-ORGANIC AND NANO-METAL CHEMISTRY, 2005, 35 (01) : 71 - 82
[9] SYNTHESIS AND CHARACTERIZATION OF DIOXOMOLYBDENUM(VI) COMPLEXES OF DIHYDRAZONES
HAVANUR, GH
MAHALE, VB
[J]. INDIAN JOURNAL OF CHEMISTRY SECTION A-INORGANIC BIO-INORGANIC PHYSICAL THEORETICAL & ANALYTICAL CHEMISTRY, 1987, 26 (12): : 1063 - 1065
[10] SYNTHESIS AND CHARACTERIZATION OF SOME PEROXO COMPLEXES OF MOLYBDENUM(VI) AND DIOXOURANIUM(VI)
ISLAM, MS
ISLAM, MN
UDDIN, MM
[J]. INDIAN JOURNAL OF CHEMISTRY SECTION A-INORGANIC BIO-INORGANIC PHYSICAL THEORETICAL & ANALYTICAL CHEMISTRY, 1994, 33 (11): : 1028 - 1030

← 1 2 3 4 5 →