Asymmetric total synthesis of natural diheteropeptin

被引:4
|
作者
Durand, P [1 ]
Peralba, P [1 ]
Derain, V [1 ]
Komesli, S [1 ]
Renaut, P [1 ]
机构
[1] Lab Fournier SA, F-21121 Daix, France
关键词
asymmetric dihydroxylation; amino acid synthesis; diheteropeptin; cyclic peptide;
D O I
10.1016/S0040-4039(01)00139-3
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A total asymmetric synthesis of diheteropeptin and a stereomer from the known (E)-1-iodo-6-octene, using the Schollkopf method for amino acid synthesis and Sharpless asymmetric dihydroxylation as key steps, is described. The asymmetric synthesis of a new unsaturated amino acid is also described. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:2121 / 2124
页数:4
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