Stereoselective synthesis of new enantiomerically enriched N-protected γ-amino acetylenic esters.

被引：11

作者：

Reginato, G ^{[1
]}

Mordini, A

Capperucci, A

Degl'Innocenti, A

Manganiello, S

机构：

[1] CNR, Ctr Chim & Struttura Composti Eterociclici & Loro, I-00185 Rome, Italy

[2] Dipartimento Chim Organ U Schiff, I-50121 Florence, Italy

来源：

TETRAHEDRON | 1998年 / 54卷 / 34期

关键词：

alkynes; amino acids and derivatives; amino aldehydes; carboxylation;

D O I：

10.1016/S0040-4020(98)00623-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new class of differently protected chiral gamma-amino acetylenic esters have been synthesized using natural occuring amino acids as chiral source. Enantiomerically enriched propargylamines or vinyldibromides have been treated with BuLi at low temperature affording, after carboxylation, enantiomerically enriched derivatives of alkynologous amino esters. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：10217 / 10226

页数：10

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