BF3•Et2O-Mediated annulation of α-keto acids with aliphatic ketones for the synthesis of γ-hydroxy-butenolides and γ-alkylidene-butenolides

被引：5
|
作者：
Cheng, Zhenfeng [1 ]
Gu, Qingyun [1 ]
Xie, Yushan [1 ]
Zhang, Yanan [1 ]
Zeng, Xiaobao [1 ]
机构：
[1] Nantong Univ, Sch Pharm, Nantong 226001, Peoples R China
来源：
RSC ADVANCES | 2022年 / 12卷 / 37期
关键词：
DECARBOXYLATIVE ACYLATION; SUBSTITUTED BUTENOLIDES; SESQUITERPENE LACTONES; ALKYNES; ROOTS; ROUTE;
D O I：
10.1039/d2ra04546j
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Annulation reaction of alpha-keto acids with cyclic or acyclic aliphatic ketones is reported herein to divergently access gamma-hydroxy-butenolides and gamma-alkylidene-butenolides depending on the amount of BF3 center dot Et2O. This protocol features good functional tolerance and ease of operation, to open a route to access butenolides via an annulation and dehydration process.
引用
收藏
页码：24237 / 24241
页数：5
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