Postconditioning in acute myocardial infarction: Primary angioplasty revisited?

被引：0

作者：

Monassier, J. -P. ^{[1
]}

Shayne, J. ^{[1
]}

Sommier, J. -M. ^{[1
]}

Schultz, R. ^{[1
]}

Ider, O. ^{[1
]}

机构：

[1] Fdn Diaconat, Unite Cardiol Intervent, F-68067 Mulhouse, France

来源：

ANNALES DE CARDIOLOGIE ET D ANGEIOLOGIE | 2010年 / 59卷 / 05期

关键词：

Reperfusion injury; Primary angioplastie; Calcium overload; Mitochondrial transition permeability pore; Postconditioning; Thrombectomy; PERCUTANEOUS CORONARY INTERVENTION; PERMEABILITY TRANSITION PORE; CONTRACTION BAND NECROSIS; ISCHEMIC CELL-DEATH; REPERFUSION INJURY; VENTRICULAR-FIBRILLATION; THROMBOLYTIC THERAPY; WAVEFRONT PHENOMENON; DISTAL EMBOLIZATION; ACUTE PHASE;

D O I：

10.1016/j.ancard.2010.08.015

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Early reperfusion of ischemic myocardium is the mean to improve prognosis of acute myocardial infarction. Nevertheless, reperfusion injury due to immediate acidosis correction and subsequent Ca2+ overload results in formation of the mitochondrial permeability transition pore. The consequence is the death of viable myocardium due to onconecrosis and apoptosis. Mechanical (Stuttering reperfusion) or pharmacological postconditioning (cyclosporine A. adenosine ... ) is able to prevent reperfusion injury resulting in more myocardial salvage. (C) 2010 Elsevier Masson SAS. All rights reserved.

引用

页码：294 / 305

页数：12

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