Research progress on the mechanism of beta-cell apoptosis in type 2 diabetes mellitus

被引：20

作者：

You, SuFang ^{[1
,2
]}

Zheng, JingYi ^{[2
]}

Chen, YuPing ^{[2
]}

Huang, HuiBin ^{[2
]}

机构：

[1] Fujian Med Univ, Clin Med Coll 2, Quanzhou, Peoples R China

[2] Fujian Med Univ, Affiliated Hosp 2, Dept Endocrinol, Quanzhou, Peoples R China

来源：

FRONTIERS IN ENDOCRINOLOGY | 2022年 / 13卷

关键词：

type; 2; diabetes; beta-cell; apoptosis; glucolipotoxicity; non-coding RNAs; exosomes; molecular mechanisms; ISLET AMYLOID POLYPEPTIDE; FREE FATTY-ACIDS; ENDOPLASMIC-RETICULUM; INSULIN TRANSCRIPTION; GLUCOSE-METABOLISM; PANCREATIC-ISLETS; ADIPOSE-TISSUE; PROTEIN; ACTIVATION; AUTOPHAGY;

D O I：

10.3389/fendo.2022.976465

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Type 2 diabetes mellitus(T2DM) is regarded as one of the most severe chronic metabolic diseases worldwide, which poses a great threat to human safety and health. The main feature of T2DM is the deterioration of pancreatic beta-cell function. More and more studies have shown that the decline of pancreatic beta-cell function in T2DM can be attributable to beta-cell apoptosis, but the exact mechanisms of beta-cell apoptosis in T2DM are not yet fully clarified. Therefore, in this review, we will focus on the current status and progress of research on the mechanism of pancreatic beta-cell apoptosis in T2DM, to provide new ideas for T2DM treatment strategies.

引用

页数：15

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