Testing the Anna Karenina Principle in Human Microbiome-Associated Diseases

被引:57
|
作者
Ma, Zhanshan [1 ,2 ]
机构
[1] Chinese Acad Sci, Kunming Inst Zool, Computat Biol & Med Ecol Lab, State Key Lab Genet Resources & Evolut, Kunming, Yunnan, Peoples R China
[2] Chinese Acad Sci, Ctr Excellence Anim Evolut & Genet, Kunming, Yunnan, Peoples R China
基金
中国国家自然科学基金;
关键词
GUT MICROBIOTA; PERIODONTITIS; HEALTH;
D O I
10.1016/j.isci.2020.101007
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The AKP (Anna Karenina principle), which refers to observations inspired by the opening line of Leo Tolstoy's Anna Karenina, "all happy families are all alike; each unhappy family is unhappy in its own way,'' predicts that all "healthy'' microbiomes are alike and each disease-associated microbiome is "sick'' in its own way in human microbiome-associated diseases (MADs). The AKP hypothesis predicts the rise of heterogeneity/stochasticity in human microbiomes associated with dysbiosis due to MADs. We used the beta-diversity in Hill numbers and stochasticity analysis to detect AKP and anti-AKP effects. We tested the AKP with 27 human MAD studies and discovered that the AKP, anti-AKP, and non-AKP effects were exhibited in approximately 50%, 25%, and 25% of the MAD cases, respectively. Mechanistically, AKP effects are primarily influenced by highly dominant microbial species and less influenced by rare species. In contrast, all species appear to play equal roles in influencing anti-AKP effects.
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收藏
页数:21
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