Microwave-assisted Michael reactions of 3-(2′-nitrovinyl)indole with indoles on TLC-grade silica gel.: A new, facile synthesis of 2,2-bis(3′-indolyl)nitroethanes

被引：65
|
作者：
Chakrabarty, M [1 ]
Basak, R [1 ]
Ghosh, N [1 ]
机构：
[1] Bose Inst, Dept Chem, Kolkata 700009, W Bengal, India
来源：
TETRAHEDRON LETTERS | 2001年 / 42卷 / 23期
关键词：
nitrovinylindole; microwave; solid surface; Michael reaction; bisindolynitroethanes;
D O I：
10.1016/S0040-4039(01)00581-0
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
3-(2 ' -Nitrovinyl)indole reacted with indole and 1- and 2-alkylindoles on TLC-grade silica gel under microwave irradiation to furnish in 7-10 min bis(indolyl)nitroethanes in high yields (70 86%). The same products were also obtained in 69-84% yields without microwave irradiation, but the reactions required 8-14 h for completion. Skatole was inert under both sets of conditions. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：3913 / 3915
页数：3
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  • [1] Michael reaction of indoles with 3-(2′-nitrovinyl)indole under solvent-free conditions and in solution.: An efficient synthesis of 2,2-bis(indolyl)nitroethanes and studies on their reduction
    Chakrabarty, M
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    [J]. TETRAHEDRON, 2004, 60 (08) : 1941 - 1949
  • [2] Michael reaction of indoles with 3-(2′-nitrovinyl)indole under solvent-free conditions and in solution.: An efficient synthesis of 2,2-bis(indolyl)nitroethanes and studies on their reduction (vol 60, pg 1941, 2004)
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