We investigated the adherence characteristics of Staphylococcus aureus and coagulase-negative staphylococci (CNS) isolated from various skin lesions by examining hydrophobicity, negative charge, tube adherence, slime production, and promotion of adherence to coverslips by blood proteins. Our results in the present study indicate that high hydrophobicity and high capacity for adhesion to tubes with slime production are much more detected in CNS from infective origin than in those from colonization origin. The results also indicate that host plasma tends to enhance adherence of S. aureus to coverslips, but it does not enhance adherence of most coagulase-negative staphylococci to coverslips. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.